临床数据通常由于其高度机密性而无法自由分发，这阻碍了医疗保健领域的机器学习的发展。缓解此问题的一种方法是使用生成对抗网络（GAN）生成现实的合成数据集。然而，已知甘恩会遭受模式崩溃的困扰，从而产生低脱水量的输出。在本文中，我们扩展了经典的GAN设置，并具有外部内存，以重播真实样品的功能。使用抗逆转录病毒治疗作为人类免疫缺陷病毒（艾滋病毒的ART）作为案例研究，我们表明我们的扩展设置增加了收敛性，更重要的是，它有效地捕获了现实世界中临床数据常见的严重类别不平衡分布。

这两个合成数据集包括3,910名急性低血压患者的生命体征，实验室测试结果，施用流体荧光剂和血管加压剂，并在重症监护病房（ICU）中为2,164名败血症患者。使用先前发布的包含和排除标准建立患者群组，并使用生成的对抗网络（GANS）和MIMIC-III临床数据库创建数据。与这些数据的释放相关的身份公开的风险估计非常低（0.045％）。将数据集作为健康健身房的一部分发布，该项目旨在公开分布用于开发机器学习算法的合成纵向健康数据（特别关注离线强化学习）和教育目的。

This paper expounds the design and control of a new Variable Stiffness Series Elastic Actuator (VSSEA). It is established by employing a modular mechanical design approach that allows us to effectively optimise the stiffness modulation characteristics and power density of the actuator. The proposed VSSEA possesses the following features: i) no limitation in the work-range of output link, ii) a wide range of stiffness modulation (~20Nm/rad to ~1KNm/rad), iii) low-energy-cost stiffness modulation at equilibrium and non-equilibrium positions, iv) compact design and high torque density (~36Nm/kg), and v) high-speed stiffness modulation (~3000Nm/rad/s). Such features can help boost the safety and performance of many advanced robotic systems, e.g., a cobot that physically interacts with unstructured environments and an exoskeleton that provides physical assistance to human users. These features can also enable us to utilise variable stiffness property to attain various regulation and trajectory tracking control tasks only by employing conventional controllers, eliminating the need for synthesising complex motion control systems in compliant actuation. To this end, it is experimentally demonstrated that the proposed VSSEA is capable of precisely tracking desired position and force control references through the use of conventional Proportional-Integral-Derivative (PID) controllers.

Due to the environmental impacts caused by the construction industry, repurposing existing buildings and making them more energy-efficient has become a high-priority issue. However, a legitimate concern of land developers is associated with the buildings' state of conservation. For that reason, infrared thermography has been used as a powerful tool to characterize these buildings' state of conservation by detecting pathologies, such as cracks and humidity. Thermal cameras detect the radiation emitted by any material and translate it into temperature-color-coded images. Abnormal temperature changes may indicate the presence of pathologies, however, reading thermal images might not be quite simple. This research project aims to combine infrared thermography and machine learning (ML) to help stakeholders determine the viability of reusing existing buildings by identifying their pathologies and defects more efficiently and accurately. In this particular phase of this research project, we've used an image classification machine learning model of Convolutional Neural Networks (DCNN) to differentiate three levels of cracks in one particular building. The model's accuracy was compared between the MSX and thermal images acquired from two distinct thermal cameras and fused images (formed through multisource information) to test the influence of the input data and network on the detection results.

Rapid advancements in collection and dissemination of multi-platform molecular and genomics data has resulted in enormous opportunities to aggregate such data in order to understand, prevent, and treat human diseases. While significant improvements have been made in multi-omic data integration methods to discover biological markers and mechanisms underlying both prognosis and treatment, the precise cellular functions governing these complex mechanisms still need detailed and data-driven de-novo evaluations. We propose a framework called Functional Integrative Bayesian Analysis of High-dimensional Multiplatform Genomic Data (fiBAG), that allows simultaneous identification of upstream functional evidence of proteogenomic biomarkers and the incorporation of such knowledge in Bayesian variable selection models to improve signal detection. fiBAG employs a conflation of Gaussian process models to quantify (possibly non-linear) functional evidence via Bayes factors, which are then mapped to a novel calibrated spike-and-slab prior, thus guiding selection and providing functional relevance to the associations with patient outcomes. Using simulations, we illustrate how integrative methods with functional calibration have higher power to detect disease related markers than non-integrative approaches. We demonstrate the profitability of fiBAG via a pan-cancer analysis of 14 cancer types to identify and assess the cellular mechanisms of proteogenomic markers associated with cancer stemness and patient survival.

Recent increases in the computational demands of deep neural networks (DNNs) have sparked interest in efficient deep learning mechanisms, e.g., quantization or pruning. These mechanisms enable the construction of a small, efficient version of commercial-scale models with comparable accuracy, accelerating their deployment to resource-constrained devices. In this paper, we study the security considerations of publishing on-device variants of large-scale models. We first show that an adversary can exploit on-device models to make attacking the large models easier. In evaluations across 19 DNNs, by exploiting the published on-device models as a transfer prior, the adversarial vulnerability of the original commercial-scale models increases by up to 100x. We then show that the vulnerability increases as the similarity between a full-scale and its efficient model increase. Based on the insights, we propose a defense, $similarity$-$unpairing$, that fine-tunes on-device models with the objective of reducing the similarity. We evaluated our defense on all the 19 DNNs and found that it reduces the transferability up to 90% and the number of queries required by a factor of 10-100x. Our results suggest that further research is needed on the security (or even privacy) threats caused by publishing those efficient siblings.

The highest grossing media franchise of all times, with over \$90 billion in total revenue, is Pokemon. The video games belong to the class of Japanese Role Playing Games (J-RPG). Developing a powerful AI agent for these games is very hard because they present big challenges to MinMax, Monte Carlo Tree Search and statistical Machine Learning, as they are vastly different from the well explored in AI literature games. An AI agent for one of these games means significant progress in AI agents for the entire class. Further, the key principles of such work can hopefully inspire approaches to several domains that require excellent teamwork under conditions of extreme uncertainty, including managing a team of doctors, robots or employees in an ever changing environment, like a pandemic stricken region or a war-zone. In this paper we first explain the mechanics of the game and we perform a game analysis. We continue by proposing unique AI algorithms based on our understanding that the two biggest challenges in the game are keeping a balanced team and dealing with three sources of uncertainty. Later on, we describe why evaluating the performance of such agents is challenging and we present the results of our approach. Our AI agent performed significantly better than all previous attempts and peaked at the 33rd place in the world, in one of the most popular battle formats, while running on only 4 single socket servers.

Unlike tabular data, features in network data are interconnected within a domain-specific graph. Examples of this setting include gene expression overlaid on a protein interaction network (PPI) and user opinions in a social network. Network data is typically high-dimensional (large number of nodes) and often contains outlier snapshot instances and noise. In addition, it is often non-trivial and time-consuming to annotate instances with global labels (e.g., disease or normal). How can we jointly select discriminative subnetworks and representative instances for network data without supervision? We address these challenges within an unsupervised framework for joint subnetwork and instance selection in network data, called UISS, via a convex self-representation objective. Given an unlabeled network dataset, UISS identifies representative instances while ignoring outliers. It outperforms state-of-the-art baselines on both discriminative subnetwork selection and representative instance selection, achieving up to 10% accuracy improvement on all real-world data sets we use for evaluation. When employed for exploratory analysis in RNA-seq network samples from multiple studies it produces interpretable and informative summaries.

Object instance segmentation is a key challenge for indoor robots navigating cluttered environments with many small objects. Limitations in 3D sensing capabilities often make it difficult to detect every possible object. While deep learning approaches may be effective for this problem, manually annotating 3D data for supervised learning is time-consuming. In this work, we explore zero-shot instance segmentation (ZSIS) from RGB-D data to identify unseen objects in a semantic category-agnostic manner. We introduce a zero-shot split for Tabletop Objects Dataset (TOD-Z) to enable this study and present a method that uses annotated objects to learn the ``objectness'' of pixels and generalize to unseen object categories in cluttered indoor environments. Our method, SupeRGB-D, groups pixels into small patches based on geometric cues and learns to merge the patches in a deep agglomerative clustering fashion. SupeRGB-D outperforms existing baselines on unseen objects while achieving similar performance on seen objects. Additionally, it is extremely lightweight (0.4 MB memory requirement) and suitable for mobile and robotic applications. The dataset split and code will be made publicly available upon acceptance.

A self-supervised adaptive low-light video enhancement (SALVE) method is proposed in this work. SALVE first conducts an effective Retinex-based low-light image enhancement on a few key frames of an input low-light video. Next, it learns mappings from the low- to enhanced-light frames via Ridge regression. Finally, it uses these mappings to enhance the remaining frames in the input video. SALVE is a hybrid method that combines components from a traditional Retinex-based image enhancement method and a learning-based method. The former component leads to a robust solution which is easily adaptive to new real-world environments. The latter component offers a fast, computationally inexpensive and temporally consistent solution. We conduct extensive experiments to show the superior performance of SALVE. Our user study shows that 87% of participants prefer SALVE over prior work.